The Saints and Dolphins have met 10 times in the regular season with Miami holding a 6-4 all-time series edge. The Saints captured the last contest, a 46-34 victory on October 25, 2009 at Land Shark Stadium in Miami Gardens, Fla., when New Orleans matched their biggest comeback in franchise history when they rebounded from a 24-3 deficit with five seconds left in the first half. This will be the first regular season meeting between the two teams in the Superdome since an October 15, 1995 33-30 Saints win. The October 20, 2005 tilt was originally scheduled to be played in New Orleans, but had to be relocated to LSU's Tiger Stadium due to Hurricane Katrina.
The two teams first faced off in 1970, as the Saints lost 21-10 in a game played at the historic Orange Bowl. The Saints would lose two more contests to the Dolphins before finally breaking through with a 17-7 victory on October 2, 1983 at the Superdome. The Saints have posted a 3-1 record against the Dolphins in meetings played in the Mercedes-Benz Superdome:
| Date | Result | Site | Attendance |
| 11/15/70 | L, 10-21 | Orange Bowl | 42,866 |
| 11/10/74 | L, 0-21 | Tulane Stadium | 74,289 |
| 9/28/80 | L, 16-21 | Orange Bowl | 40,946 |
| 10/2/83 | W, 17-7 | Superdome | 66,489 |
| 12/7/86 | L, 27-31 | Superdome | 64,761 |
| 11/29/92 | W, 24-13 | Superdome | 68,591 |
| 10/15/95 | W, 33-30 | Superdome | 45,517 |
| 11/29/98 | L, 10-30 | Pro Player Stadium | 73,216 |
| 10/30/05 | L, 16-21 |
Tiger Stadium | 61,643 |
| 10/25/09 | W, 46,34 | Land Shark Stadium | 66,689 |
