*Bills cornerback Ron Brooks, quarterback Matt Flynn, and defensive end Kyle Williamswere all on National Championship teams at LSU, with Flynn and Brooks winning in '07 and Williams in '03.
*Bills cornerback Justin Rogersis a Baton Rouge Native who prepped at Redemptorist HS.
*Running back Mark Ingram and Buffalo tackle Marcell Dareuswon a national title together at Alabama.
*Inside linebacker Kevin Reddickand Bills safety Da'Norris Searcywere college teammates at the University of North Carolina.
*Inside linebacker David Hawthorneand Buffalo linebacker Jerry Hughesplayed on the same defensive unit at TCU.
*Outside linebacker Keyunta Dawsonand inside linebacker Ramon Humberplayed with Hughes with the Indianapolis Colts.
*Saints safety Kenny Vaccarowill square off against his former University of Texas teammates safety Aaron Williamsand wide receiver Marquise Goodwin.
*Wide receiver Nick Toonwas teammates with guard Kraig Urbikat Wisconsin.
*Bills Head Coach Doug Marroneserved as the Saints offensive coordinator/offensive line coach under New Orleans Head Coach Sean Paytonfrom 2006-08. Marrone also played for the Saints in 1989.
*Buffalo Head strength and conditioning coach Eric Cianoserved in the same capacity for Louisiana Tech from 2000-02.
*Bills linebackers coach Chuck Driesbachhas two stints at the University of Mississippi, serving as the secondary coach (1989) and as defensive coordinator (2002-04).
*Buffalo Defensive Backs Coach Donnie Hendersonwas the defensive coordinator for the New York Jets from 2004-2005, serving as a tutor for ILB Jonathan Vilma. Henderson also served as secondary coach at Southern in 2011.
*Bills Director of Player Personnel Jim Monosspent the past eight seasons as an area scout for the Saints.
*Executive Vice President/General Manager Mickey Loomisand Buffalo General Manager Doug Whaleyserved in the same Seattle front office from 1996-97.
*Wide Receivers Coach HenryEllard, Buffalo Defensive Coordinator Mike Pettineand Linebackers Coach Jim O'Neilserved on the same staff with the New York Jets from 2009-11.
*Ellard and Bills Assistant Defensive Backs Coach Samson Brownalso served on the same Jets staff from 2010-11.
*Assistant Special Teams Coach Stan Kwanserved in the same capacity with the Bills from 2010-12.
*Kwan and Buffalo Offensive Line Coach Pat Morrisserved on the same staff in Detroit from 2004-05.
*Bills Wide Receivers Coach Ike Hilliardis a Patterson native who is the nephew of former Saints RB Dalton Hilliard. Hillard played under Payton with the New York Giants from 2000-02.