New Orleans Saints QB Drew Brees will be a guest on the "The Late Show with David Letterman" Wednesday at 10:35 pm CT.
Also on Wednesday's show, a Top Ten List presented by NBA Commissioner David Stern, actor/author B.J. Novak and musical guests Against Me!
Wednesday's night's appearance will mark Brees' fourth time on the show.
![](http://www.neworleanssaints.com/media-center/photo-gallery/Drew-Brees-Top-100-Photos-of-2013/b3e709ec-4761-4704-891b-a35e0fecbb7a "new orleans saints")