Opponent – San Francisco 49ers
Coach – Kyle Shanahan
Quarterback – Jimmy Garoppolo
2018 record – 4-12, third in NFC West
Most recent regular season matchup: Sunday, Nov. 6, 2016: Saints 41, 49ers 23
2019 game: Sunday, Dec. 6 – Week 14 at noon on Fox
Stadium – Mercedes-Benz Superdome
49ers-Saints series record: 49ers lead 48-26-2

49ers' 2018 season recap:

The San Francisco 49ers were unable to live up to their high expectations this past season. The 49ers' season ended with a record of 4–12 as the team was hit with multiple season-ending injuries, which included running back Jerick McKinnon tearing his ACL in training camp and quarterback Jimmy Garoppolo tearing his ACL in Week 3 against the Kansas City Chiefs. The 49ers were eliminated from playoff contention following a Week 13 loss to the Seattle Seahawks. In week 15, the 49ers upset the Seahawks 26–23 in overtime at home, snapping the 49ers' 10-game losing streak to Seattle that dated to the 2013 playoffs.

Notable additions:

• Linebacker – Dee Ford
• Linebacker – Kwon Alexander
• Running back – Tevin Coleman

Notable losses:

• Wide receiver – Pierre Garçon
• Running back – Alfred Morris
• Punter – Bradley Pinion