The Saints and Buccaneers first met in 1977. New Orleans has posted a 32-20 record vs. Tampa Bay, the club's best winning percentage (.625) vs. an opponent they have played a minimum of seven games against.In the 52 games of the series there has been:
- 1,148 points scored by New Orleans, 965 allowed
- A seven-game New Orleans winning streak from 2011- 2014
- An 18-9 record for the Saints in games played in New Orleans
- 20 games decided by double-digits
- Seven games decided by 21 or more points
- 32 games decided by seven points or less
- A 41-point win by New Orleans on December 16, 2012, the club's first shutout against the Buccaneers
