Play-By-Play | Buffalo Bills at New Orleans Saints 2021 NFL Week 12 | NewOrleansSaints.com

Check out the best shots of our Saints fans at home for Week 12 action between the New Orleans Saints and Buffalo Bills on Thanksgiving night.

New Orleans Saints linebacker Kwon Alexander comes up with the finger-tip interception off Josh Allen and the Bills on Thursday Night Football in Week 12 of the 2021 NFL season. Saints senior writer John DeShazier breaks it down in this week's Expert Analysis presented by Microsoft Surface.

A collection of the best offensive photos from the Week 12 loss against the Buffalo Bills.

'There's a lot of things on (the film review) that aren't good enough'

New Orleans Saints legend Drew Brees returned to the Caesars Superdome on Thanksgiving night as the Saints take on the Buffalo Bills on November 25, 2021.

The New Orleans Saints take on the Buffalo Bills at the Caesars Superdome in Week 12 of the 2021 NFL season.

New Orleans Saints fans swarm the Caesars Superdome to cheer on the team against the Buffalo Bills on Thanksgiving night and welcome legend Drew Brees back to the Dome.

Saints turned over ball on downs after beginning drive at own 49

Saints head coach and players speak following the Week 12 loss against the Buffalo Bills

Second-quarter interception stopped Bills in red zone

New Orleans' 2021 home record is 2-3

Offense totaled 190 yards in 31-6 loss

Buffalo Bills at New Orleans Saints game highlights from Thanksgiving night on Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints center Erik McCoy's postgame interview following the Saints' Thanksgiving night loss to the Buffalo Bills on Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints defensive end Cameron Jordan's postgame interview following the Saints' Thanksgiving night loss to the Buffalo Bills on Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints linebacker Kwon Alexander's postgame interview following the Saints' Thanksgiving night loss to the Buffalo Bills on Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints quarterback Trevor Siemian's postgame interview following the Saints' Thanksgiving night loss to the Buffalo Bills on Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints head coach Sean Payton's postgame interview following the Saints' Thanksgiving night loss to the Buffalo Bills on Thursday Night Football in week 12 of the 2021 NFL season.

Saints lose fourth consecutive game

New Orleans Saints quarterback Trevor Siemian finds tight end Nick Vannett in the back of the end zone for the touchdown against the Buffalo Bills on Thanksgiving night for Thursday Night Football in week 12 of the 2021 NFL season.

New Orleans Saints quarterback Trevor Siemian stands strong in pocket to deliver 24-yard catch and run to Lil'Jordan Humphrey  against the Buffalo Bills on Thanksgiving night for Thursday Night Football in week 12 of the 2021 NFL season.

Go inside Caesars Superdome for Thursday Night Football as a full capacity crowd give thanks to Drew Brees as he returns the favor on Thanksgiving during halftime of the New Orleans Saints' game vs the Buffalo Bills in week 12 of the 2021 NFL season.

New Orleans Saints linebacker Kwon Alexander intercepts a pass thrown by Buffalo Bills quarterback Josh Allen right before halftime on Thanksgiving night for Thursday Night Football in week 12 of the 2021 NFL season.

Harry Connick Jr., Carli Lloyd, Matthew McConaughey, Vince Vaughn, and Wendell Pierce reminisce about the impact of New Orleans Saints legend Drew Brees and his lasting legacy on and off the field.

Saints shut out in first half, have just 64 yards of offense