The Saints will welcome the Bills (7:20 p.m. CDT) on Thanksgiving Day 2021. New Orleans throttled Buffalo 47-10 in Week 10 of the 2017 season. Saints wideout Michael Thomas hauled in nine receptions for 117 yards in the contest.
Saints vs Bills Tickets and History for Week 12 on November 25, 2021
History: New Orleans Saints vs. Buffalo Bills
The Saints lead the all-time series 7-4, holding a five-game winning streak against the Bills. New Orleans has posted a 3-3 mark in home contests played against Buffalo, winning in three different facilities; Tulane Stadium (1973), San Antonio's Alamodome (2005) and the Mercedes-Benz Superdome (2013). Kamara had the first 100-yard rushing game of his four-year career against the Bills when he carried 12 times for 106 yards with one touchdown in a 47-10 Saints win at Buffalo's New Era Field on November 12, 2017.
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Cameron Jordan, Lance Nichols debut The Season | 2021 Saints Schedule Release
Catch the debut of 'The Season' this fall as Cameron Jordan and his team of warriors will march, confronting enemies near and far to defend what is theirs. Official 2021 Saints Schedule Release presented by SeatGeek.
New Orleans Saints 2021 Schedule presented by SeatGeek announced
Saints 2021 regular season kicks off against Green Bay on Sept. 12
Photos: Behind-the-scenes at Saints 2021 Schedule Release video shoot
Get a behind-the-scenes look at the making of the New Orleans Saints 2021 NFL Schedule release video featuring defensive end
New Orleans Saints remain prime-time draw for 2021 NFL season
Saints have five schedule national TV games; open season vs. Green Bay on Sept. 12
2021 Saints Schedule Release Show: Breakdown & Analysis
John DeShazier and Caroline Gonzalez break down the New Orleans Saints 2021 NFL regular season schedule and highlight the key matchups coming to the Mercedes-Benz Superdome.
New Orleans Saints 2021 Opponents: Coaches
The New Orleans Saints have announced their schedule for the 2021 season. Take a look at the NFL head coaches that Sean Payton will go head-to-head against in the regular season.
New Orleans Saints 2021 Opponents: Quarterbacks
The New Orleans Saints have announced their schedule for the 2021 season. Take a look at the NFL quarterbacks that the Saints will go head-to-head against in the regular season.