The New Orleans Saints will host the Arizona Cardinals in Week 16 on December 27, 2026 at Noon CT. on FOX. The Saints host Arizona in the Caesars Superdome for the second consecutive season and will look to get revenge after the team opened the 2025 season against the Cardinals in a down-to-the-wire 20-13 Saints defeat.
In 32 all-time regular season series meetings, Arizona holds a 17–15 overall advantage over New Orleans. The Saints captured their lone postseason matchup with a 45-14 victory in the 2009 NFC Divisional round. The most recent matchup took place in 2025 at the Caesars Superdome, where the Cardinals defeated the Saints 20–13.
Head Coach: Mike LaFleur
Quarterback: Jacoby Brissett
Key Position Players: WR Marvin Harrison Jr., TE Trey McBride, RB Jeremiyah Love, S Budda Baker, OLB Josh Sweat
Head Coach: Kellen Moore
Quarterback: Tyler Shough
Key Position Players: RB Alvin Kamara, WR Chris Olave, TE Juwan Johnson, LB Pete Werner, EDGE Carl Granderson
