The Saints and Cardinals have played 26 times in the regular season, with the Saints trailing 12-14. The Cardinals won the first three games, including both played in 1968 when they were in the NFL Century division. The Saints won their first game against the Cardinals on Nov. 2, 1969, 51-42 at Busch Stadium. The game still stands as the most points between two clubs in team history. The clubs combined for 80 points on Oct. 23, 1977 at St. Louis in a 49-31 Cardinals win. In another memorable contest, the Saints beat the Cardinals 14-0 on Dec. 8, 1974 in the team's final contest played at Tulane Stadium:
| Date | Result | Site | Attendance |
| 12/3/67 | L, 20-31 | Busch Stadium | 41,171 |
| 9/29/68 | L, 20-21 | Tulane Stadium | 79,021 |
| 10/27/68 | L, 17-31 | Busch Stadium | 45,476 |
| 11/2/69 | W, 51-42 | Busch Stadium | 46,718 |
| 10/11/70 | L, 17-24 | Busch Stadium | 45,294 |
| 12/8/74 | W, 14-0 | Tulane Stadium | 57,152 |
| 10/23/77 | L, 31-49 | Busch Stadium | 48,417 |
| 10/5/80 | L, 7-40 | Superdome | 45,388 |
| 12/6/81 | L, 3-30 | Busch Stadium | 46,923 |
| 9/12/82 | L, 7-21 | Superdome | 58,673 |
| 9/4/83 | W, 28-17 | Superdome | 60,430 |
| 9/23/84 | W, 34-24 | Superdome | 58,723 |
| 12/8/85 | L, 16-28 | Busch Stadium | 29,527 |
| 11/16/86 | W, 16-7 | Busch Stadium | 32,069 |
| 10/11/87 | L, 19-24 | Busch Stadium | 11,795 |
| 9/23/90 | W, 28-7 | Superdome | 61,110 |
| 12/22/91 | W, 27-3 | Sun Devil Stadium | 30,928 |
| 10/18/92 | W, 30-21 | Sun Devil Stadium | 27,735 |
| 10/31/93 | W, 20-17 | Sun Devil Stadium | 36,778 |
| 9/22/96 | L, 14-28 | Superdome | 34,316 |
| 12/14/97 | W, 27-10 | Superdome | 45,517 |
| 12/20/98 | L, 17-19 | Sun Devil Stadium | 51,617 |
| 10/29/00 | W, 21-10 | Sun Devil Stadium | 35,016 |
| 10/3/04 | L, 10-34 | Sun Devil Stadium | 28,109 |
| 12/16/07 | W, 31-24 | Superdome | 70,007 |
| 10/10/10 | L, 20-30 | Univ. Phoenix Stadium | 62,621 |
