Saints vs. 49ers Play-by-Play - Week 2 - Sept. 14, 2025

Saints face former NFC West rival San Francisco 49ers in Week 2

The New Orleans Saints' 2025 NFL schedule is here. See every matchup, key dates, and divisional games.

Check out the game action shots from the New Orleans Saints game against the San Francisco 49ers in Week 2 of the 2024 NFL Preseason.

Check out the pregame arrivals and warm-ups from the New Orleans Saints game against the San Francisco 49ers in Week 2 of the 2024 NFL Preseason.

New Orleans Saints players in action during their 2022 Week 12 game against the San Francisco 49ers.

New Orleans Saints fans cheered on the team during 2022 Week 12 against the San Francisco 49ers on November 27, 2022 at Levi's Stadium.

Check out the team arrivals and preparations from the New Orleans Saints ahead for their Week 12 matchup against the San Francisco 49ers.

San Francisco 49ers vs. New Orleans Saints game highlights from Week 12 of the 2022 NFL season.

Photos from New Orleans Saints' walkthrough ahead of their game against the San Francisco 49ers in Week 12 of the 2022 NFL season.

Game action photos from the New Orleans Saints vs. San Francisco 49ers matchup in Week 10 of the 2020 NFL season.

Highlights from the New Orleans Saints Week 10 win vs the San Francisco 49ers during the 2020 NFL season.

Game action photos from the New Orleans Saints vs. San Francisco 49ers matchup in Week 10 of the 2020 NFL season.

New Orleans Saints fans and cheer on the team from inside the Mercedes-Benz Superdome against the San Francisco 49ers in Week 10 of the 2020 NFL season.

New Orleans Saints fans cheer on the team from a safe distance as the Saints take on the San Francisco 49ers in Week 10 of the 2020 NFL season.

Pregame photos from the New Orleans Saints playing host to the San Francisco 49ers in Week 10 of the 2020 NFL season.

The New Orleans Saints host the San Francisco 49ers at the Mercedes-Benz Superdome on Sunday, December 8, 2019.

Several New Orleans Saints players wore custom footwear as part of the NFL's My Cause, My Cleats campaign for Week 14 against the San Francisco 49ers.

Check out the on-field entertainment during the Week 14 matchup between the Saints and 49ers at the Mercedes-Benz Superdome.

The New Orleans Saints host the San Francisco 49ers at the Mercedes-Benz Superdome on Sunday, December 8, 2019.

New Orleans Saints fans cheer on the team against the San Francisco 49ers at the Mercedes-Benz Superdome.

New Orleans Saints players prepare for week 14 before taking on the San Francisco 49ers at the Mercedes-Benz Superdome.

The Saintsations took to the field and performed for fans during Week 14 between the Saints and 49ers at the Mercedes-Benz Superdome.

New Orleans Saints fans get ready for Week 14 against the San Francisco 49ers during our pregame party at Champions Square presented by Ticketmaster.

Take a look back through the years in the old NFC West through present day and view photos from the storied Saints-49ers rivalry.

Saints players celebrate their Week 9 victory over the 49ers in San Francisco.