Saints vs. 49ers Play-by-Play - Week 2 - Sept. 14, 2025

Check out the 30 best photos of the New Orleans defense in their game against the San Francisco 49ers for Week 2 of the 2025 NFL Season on Sept. 14, 2025 at Caesars Superdome.

Check out the 30 best photos of the New Orleans offense in their game against the San Francisco 49ers for Week 2 of the 2025 NFL Season on Sept. 14, 2025 at Caesars Superdome.

Quotes from Kellen Moore, Spencer Rattler, Demario Davis, Devaughn Vele, and Cam Jordan

New Orleans held San Francisco to 77 yards rushing on 26 carries

Quarterback Spencer Rattler: 'We're close, though. We're close'

Watch full game highlights from the New Orleans Saints vs. San Francisco 49ers game in Week 2 of the 2025 NFL season.

New Orleans Saints linebacker Demario Davis' postgame interview after the Saints' game vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saints head coach Kellen Moore's postgame interview after the Saints' game vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saints quarterback Spencer Rattler's postgame interview after the Saints' game vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saints safety Justin Reid's postgame interview after the Saints' game vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saints defensive end Cameron Jordan's postgame interview after the Saints' game vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

Check out the game action photos from the New Orleans Saints game against the San Francisco 49ers for Week 2 of the 2025 NFL season on Sept. 14, 2025 at Caesars Superdome.

Check out the fan photos from the New Orleans Saints game against the San Francisco 49ers for Week 2 of the 2025 NFL season on Sept. 14, 2025 at Caesars Superdome.

The Saints Cheer Krewe entertained our fans and John Christopher Adams performed at the national anthem during the New Orleans Saints game against the San Francisco 49ers in Week 2 of the 2025 NFL season on Sept. 14 in the Caesars Superdome.

Saints fall to 0-2 with loss at Caesars Superdome

Watch highlights of New Orleans Saints quarterback Spencer Rattler connecting with wide receiver Devaughn Vele on the 3-yard touchdown pass vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saints wide receiver Chris Olave leaps to make a 13-yard reception from Spencer Rattler inside the San Francisco 49ers 5-yard line in Week 2 of the 2025 NFL season.

Watch highlights of New Orleans Saints wide reciever Rashid Shaheed pulling in the 3-yard touchdown pass from Spencer Rattler vs. the San Francisco 49ers in Week 2 of the 2025 NFL.

New Orleans Saint quarterback Spencer Rattler uses a juke move to avoid a tackler and pick up first-down yardage on a fourth down vs. the San Francisco 49ers in Week 2 of the 2025 NFL season.

Watch highlights of New Orleans Saints defensive end Chris Rumph II with the strip sack of San Francisco 49ers quarterback Mac Jones recovered by linebacker Demario Davis in Week 2 of the 2025 NFL season.

49ers will get the ball to start the second half

Watch highlights of New Orleans Saints quarterback Spencer Rattler throwing an 18-yard touchdown pass to tight end Juwan Johnson vs. San Francisco 49ers in Week 2 of the 2025 NFL season.

New Orleans Saints quarterback Spencer Rattler shows off some physicality on a third-down scramble that nets 9 yards vs. the San Francisco 49ers in Week 2 of the 2025 NFL season.

New Orleans Saints tight end Juwan Johnson caps off his first reception of the game with a hurdle to gain first-down yardage vs. the San Francisco 49ers in Week 2 of the 2025 NFL season.

New Orleans Saints quarterback Spencer Rattler connects with wide receiver Brandin Cooks over the middle for a first-down conversion vs. the San Francisco 49ers in Week 2 of the 2025 NFL season.