The Buffalo Bills will host the New Orleans Saints in Week 4 on September 28, 2025 at noon on CBS. In 2024, the Bills finished with a 13-4 record, clinching the AFC East division and making it to the playoffs. The Saints will be facing all four of the AFC East team for the first time since 2021.
New Orleans Saints
Buffalo Bills
The New Orleans Saints and Buffalo Bills have met 12 times with New Orleans leading the series 7-5. The last matchup between the clubs took place on Thanksgiving night during the 2021 NFL season with the shorthanded Saints falling 31-6 in the Caesars Superdome.
Head Coach: Sean McDermott
Quarterback: Josh Allen
Key Position Players: RB James Cook, WR Khalil Shakir, DE Joey Bosa, WR Joshua Palmer, CB Tre'Davious White
Head Coach: Kellen Moore
Quarterback: Spencer Rattler, Jake Haener, Tyler Shough
Key Position Players: RB Alvin Kamara, WR Mason Tipton, DE Fadil Diggs, TE Juwan Johnson, DE Carl Granderson, C/G Erik McCoy
