The New Orleans Saints will host the Arizona Cardinals to open the season on September 7, 2025 in Week 1 at noon on CBS in the Caesars Superdome. The Saints face the Cardinals for the first time in the regular season since 2022 and will look to break the 16-16 tie in all-time record between the two franchises. The Cardinals finished 2024 at 8-9 and have missed the postseason in their previous three campaigns.
Arizona Cardinals at New Orleans Saints: Week 1 - September 7, 2025
