Bills vs. Saints Play-by-Play - Week 4 - Sept. 28, 2025

Check out the 25 best photos of the New Orleans defense in their game against the Buffalo Bills for Week 4 of the 2025 NFL Season on Sept. 28, 2025 at Highmark Stadium.

Check out the 25 best photos of the New Orleans offense in their game against the Buffalo Bills for Week 4 of the 2025 NFL Season on Sept. 28, 2025 at Highmark Stadium.

New Orleans Saints running back Kendre Miller speaks with the media from the Ochsner Sports Performance Center on Monday, September 29, 2025 the day after the Saints' Week 4 game against the Buffalo Bills and ahead of Week 5 against the New York Giants.

New Orleans Saints safety Jonas Sanker speaks with the media from the Ochsner Sports Performance Center on Monday, September 29, 2025 the day after the Saints' Week 4 game against the Buffalo Bills and ahead of Week 5 against the New York Giants.

New Orleans Saints head coach Kellen Moore speaks with the media from the Ochsner Sports Performance Center on Monday, September 29, 2025 the day after the Saints' Week 4 game against the Buffalo Bills and ahead of Week 5 against the New York Giants.

New Orleans Saints defensive end Cameron Jordan's postgame interview after the Saints' game at the Buffalo Bills in Week 4 of the 2025 NFL season.

New Orleans Saints running back Alvin Kamara's postgame interview after the Saints' game at the Buffalo Bills in Week 4 of the 2025 NFL season.

Cam Jordan's sack on Josh Allen surpasses Robert Mathis for 20th all-time in NFL record books

Watch highlights from the Buffalo Bills vs. New Orleans Saints game in Week 4 of the 2025 NFL season.

'We're in these games and we've just got to close them out. It's frustrating.'

The New Orleans Saints hosted a watch party presented by Bud Light for their game against the Buffalo Bills on Sept. 28, 2025 at Five O Fore Golf and Entertainment in New Orleans, Louisiana. Members of the Saints Cheer Krewe were in attendance and interacting with fans during the event.

Watch New Orleans Saints head coach Kellen Moore's postgame interview after the Saints' game at the Buffalo Bills in Week 4 of the 2025 NFL season.

New Orleans Saints quarterback Spencer Rattler's postgame interview after the Saints' game at the Buffalo Bills in Week 4 of the 2025 NFL season.

Saints drop to 0-4 after strong effort against Bills comes up short

Watch highlights of New Orleans Saints defensive end Carl Granderson with the 4th down tackle for a loss vs. the Buffalo Bills in Week 4 of the 2025 NFL season.

New Orleans Saints quarterback Spencer Rattler rushes for 11 yards against the Buffalo Bills during Week 4 of the 2025 NFL season.

Check out the fan photos from the New Orleans Saints game against the Buffalo Bills for Week 4 of the 2025 NFL Season on Sept. 28, 2025 at Highmark Stadium.

Watch highlights of New Orleans Saints quarterback Spencer Rattler threading the needle on the 3-yard touchdown pass to wide receiver Chris Olave vs. the Buffalo Bills in Week 4 of the 2025 NFL season.

Watch highlights of New Orleans Saints defensive end Carl Granderson sacking Buffalo Bills quarterback Josh Allen in Week 4 of the 2025 NFL season.

Watch highlights of New Orleans Saints defensive end Cameron Jordan with the strong sack on Josh Allen and the Buffalo Bills in Week 4 of the 2025 NFL season.

Saints will get the ball to start the second half

Watch highlights of New Orleans Saints kicker Blake Grupe drilling the 54-yard field goal to make the score 14-10 vs. the Buffalo Bills in Week 4 of the 2025 NFL season.

Watch highlights of New Orleans Saints safety Jonas Sanker covering massive ground on the interception from Buffalo Bills quarterback Josh Allen in Week 4 of the 2025 NFL season.

Check out the game action photos from the New Orleans Saints game against the Buffalo Bills for Week 4 of the 2025 NFL Season on Sept. 28, 2025 at Highmark Stadium.

Watch highlights of New Orleans Saints running back Kendre Miller breaking multiple tackles on his way to an 18-yard touchdown run vs. the Buffalo Bills in Week 4 of the 2025 NFL season.