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Game Preview: Bills vs. Saints | 2025 NFL Week 4

The New Orleans Saints visit the Buffalo Bills at Highmark Stadium for Week 4 of the 2025 NFL season on Sunday, Sept. 28 at noon CT.

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WEEK 4 · Sun 09/28 · 12:00 PM CDT

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Buffalo Bills

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Highmark Stadium

The Saints (0-3) will go back on the road for the second consecutive week to battle the Buffalo Bills (3-0) in a Week 4 meeting at Highmark Stadi­um on Sunday at 12:00 p.m. CST. The Saints will be looking to get in the win column for the first time in 2025 following a long trip back from Seattle where they fell to the Seahawks 44-13 in Week 3.

THIS WEEK IN THE NFC SOUTH: In Week 4, the rest of the NFC South will also kickoff at noon on Sept. 28 with the Atlanta Falcons (1-2) playing host to the Washington Commanders (2-1). The Panthers (1-2) hit the road to take on the New England Patriots (1-2). The Tampa Bay Buccaneers (3-0) will host the defending Super Bowl champion Philadelphia Eagles (3-0).

SAINTS vs. BILLS SEASON SERIES HISTORY

The Saints and Bills have met 12 times with New Orleans holding a 7-5 lead, having a five-game winning streak in the series broken in a 31-6 Bills win in the 2021 Thanksgiving matchup at the Caesars Superdome. The Saints have a 4-1 record in road contests, the only loss a 27-21 decision at Rich Stadium on October 30, 1983. Two of the games have been decided by a touchdown or less, one by four points. The teams first faced off in 1973, as the Saints re-corded a 13-0 shutout, the first in club history and didn't meet again for seven years.

THE LAST REGULAR SEASON MEETING

Buffalo Bills 31, New Orleans Saints 6; November 25, 2021 @ Caesars Superdome - On the night that legendary New Orleans quarterback Drew Brees said goodbye to Saints fans, the New Orleans offense had one of its least effective games as the Buffalo Bills cruised to a 31-6 victory on Thanksgiving night at the Caesars Superdome. FULL GAME RECAP

The New Orleans Saints take on the Buffalo Bills at the Caesars Superdome in Week 12 of the 2021 NFL season.

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SAINTS vs. BILLS SUPERLATIVES

A look at the top individual performances for Saints players against the Bills in the previous 12 meetings:

SAINTS RUSHING YARDAGE vs. BILLS (100+ yards)

PlayerPerformance / Location / Date
RB Mark Ingram21 carries for 131 yards, @ New Era Field, Nov. 12, 2017.
RB Deuce McAllister27 carries for 130 yards, @ the Alamodome, Oct. 2, 2005.
RB Pierre Thomas 14 carries for 126 yards, @ Ralph Wilson Stadium, Sept. 27, 2009.
RB George Rogers21 carries for 114 yards, @ Superdome, Sept. 21, 1980.
RB Alvin Kamara12 carries for 106 yards, @ New Era Field, Nov. 12, 2017.

SAINTS PASSING YARDAGE vs. BILLS (250+ yards)

PlayerPerformance / Location / Date
QB Drew Brees26 of 34 for 332 yards, @ Mercedes-Benz Superdome, Oct. 27, 2013.
QB John Fourcade15 of 27 for 302 yards, @ Rich Stadium, Dec. 10, 1989.
QB Billy Joe Tolliver 23 of 42 for 296 yards @ Superdome, Dec. 27, 1998.
QB Archie Manning24 of 34 for 285 yards @ Superdome, Sept. 21, 1980.

SAINTS RECEIVING YARDAGE vs. BILLS (100+ yards)

PlayerPerformance / Location / Date
WR Donte’ StallworthEight rec. for 129 yards, @ Alamodome, Oct. 2, 2005.
WR Kenny StillsThree rec. for 129 yards, @ Mercedes-Benz Superdome, Oct. 27, 2013.
WR Brett BechFour rec. for 113 yards, @ Superdome, Dec. 27, 1998.
TE Cameron CleelandTen rec. for 112 yards, @ Superdome, Dec. 27, 1998.
WR Eric MartinFour rec. for 100 yards, @ Rich Stadium, Dec. 10, 1989.

SAINTS vs. BILLS STATISTICAL COMPARISON

2025 NFL Regular Season League Rankings


SaintsBills
Record0-33-0
Scoring Avg. (NFL Rank)15.7 (29)34.0 (3)
Opp. Scoring Avg. (NFL Rank)30.0 (26)23.7 (20)
Total Off. (NFL Rank)311.0 (19t)420.0 (1)
Rushing Off. (NFL Rank)102.3 (18)163.0 (1)
Passing Off. (NFL Rank)199.7 (17)257.0 (6)
Total Def. (NFL Rank)313.3 (15)287.3 (9)
Rushing Def. (NFL Rank)103.3 (13)156.0 (32)
Passing Def. (NFL Rank)210.0 (17)131.3 (2)
Punt Return Avg. (NFL Rank)16.2 (6)5.3 (28)
Kickoff Return Avg. (NFL Rank)24.5 (22)27.9 (4)
Turnover Margin (NFL Rank)Even (16t)+3 (4)
Possession Avg.29:1534:59
Touchdowns512
Penalties3114
Penalty Yards211142
Opp. Penalties2218
Opp. Penalty Yards164143

SAINTS vs. BILLS SERIES FAST FACTS

as of Week 4 2025

CategoryDetails
Saints’ Largest Margin of Victory37 (Saints 47, Bills 10, Nov. 12, 2017 at New Era Field)
Bills’ Largest Margin of Victory25 (Bills 31, Saints 6, Nov. 25, 2021 at Caesars Superdome)
Current Series StreakBills 1 (Nov. 25, 2021-present)
Saints’ Longest Win Streak5 (Sept. 9, 2001-Nov. 12, 2017)
Bills’ Longest Win Streak2, 2x (Sept. 21, 1980-Oct. 30, 1983 and Dec. 20, 1992-Dec. 27, 1998)
Most Points by Saints47, (Saints 47, Bills 10, Nov. 12, 2017 at New Era Field)
Most Points by Bills45, Saints 33 (Dec. 27, 1998 at Louisiana Superdome)
Most Points, Both Teams78 (Bills 45, Saints 33, Dec. 27, 1998 at Louisiana Superdome)
Fewest Points by Saints6, Bills 31 (Nov. 25, 2021 at Caesars Superdome)
Fewest Points by Bills0, Saints 13 (Nov. 4, 1973 at Tulane Stadium)
Fewest Points Both Teams13, (Saints 13, Bills 0, Nov. 4, 1973 at Tulane Stadium)

SAINTS vs. BILLS CONNECTIONS

New Orleans Assistant Defensive Backs Coach Robert Blanton played for the Bills for 2016-17.

Saints Assistant Linebackers Coach Adam Gristick served on the Syracuse coaching staff from 2016-17.

New Orleans practice squad defensive end Fadil Diggs played at Syracuse in 2024.

Saints National Scout Terry Wooden is a former four-year stand-out at Syracuse (1986-89) and is a member of the school's All-Century team.

Saints Tight Ends Coach Chase Haslett's father, Jim, was a first round draft selection of the Bills in 1979 and was a standout linebacker for them from 1979-86.

Bills Offensive Coordinator Joe Brady served as an offensive assistant with the Saints from 2017-18 and was LSU's passing game coordinator & wide receivers coach in 2019 when the Tigers won the national championship.

Buffalo Quarterbacks Coach Ronald Curry was a member of the Saints coaching staff from 2016-23.

Buffalo Wide Receivers Coach Adam Henry was on New Orleans' offseason rosters from 1994-96, competing for a roster spot, served on the McNeese State coaching staff from 1997-2006 and served as Louisiana State University's passing game coordinator & wide receivers coach from 2012-14.

Haslett, Saints Head Coach Kellen Moore, Offensive Coord. Doug Nussmeier and Quarterbacks Coach Scott Tolzien served on the same Dallas Cowboys coaching staff with Henry from 2020-21.
Bills Offensive Quality Control Coach DJ Mangas served on LSU's coaching staff in 2019 and 2021.

New Orleans Head Athletic Trainer Shone Gipson served on the Bills training staff from 2002-17, including his final three seasons in Buffalo as head athletic trainer.

New Orleans Assistant Athletic Trainer Uriah Myrie served as an athletic training intern in Buffalo in 2014.

Buffalo Offensive Line Coach Aaron Kromer served on the New Orleans coaching staff from 2008-12, served on the same Chicago Bears staff with Saints Offensive Line Coach Brendan Nugent from 2013-14 and on the same Los Angeles Rams staff with Saints Defensive Coordinator Brandon Staley in 2020.

New Orleans defensive end Chase Young and Buffalo Offensive Quality Control Coach Kyle Shurmer and wide receiver Curtis Samuel were teammates with the Washington Commanders.

New Orleans defensive back Jordan Howden was tutored by Buffalo Cornerbacks Coach Jahmile Addae as a freshman at the University of Minnesota in 2018.

Buffalo Senior Defensive Assistant Ryan Nielsen served on the New Orleans coaching staff from 2017-22.

New Orleans defensive end Carl Granderson and Buffalo quarterback Josh Allen were college teammates at the University of Wyoming from 2015-16.

Saints tackle Xavier Truss and Buffalo running back James Cook were college teammates at the University of Georgia.

Saints defensive tackle Nathan Shepherd and Buffalo running back Ty Johnson and wide receiver Elijah Moore were teammates with the New York Jets.

Bills wide receiver Keon Coleman was a former Opelousas Catholic High School standout.

Moore tutored Bills wide receiver Joshua Palmer in 2023, when he served as offensive coordinator of the Los Angeles Chargers.

Saints running back Velus Jones Jr. and Palmer were college teammates at Tennessee.

Saints wide receiver Mason Tipton and Bills tight end Jackson Hawes were college teammates at Yale from 2020-23.

New Orleans guard/tackle Trevor Penning and Bills tackle Spencer Brown were college teammates at Northern Iowa.

New Orleans safety Terrell Burgess, defensive end Jonah Williams, safety Taylor Rapp and Bills guard David Edwards were teammates with the Los Angeles Rams.

Staley tutored Rapp in Los Angeles in 2020, when he was their defensive coordinator.

Saints practice squad quarterback Jake Haener and Rapp were teammates at the University of Washington.

Moore tutored Bills center Connor McGovern in Dallas from 2019-22.

Saints tight end Juwan Johnson and McGovern were college teammates at Penn State from 2016-18.

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