Bills vs. Saints Game Center - Week 4 - Sept. 28, 2025

Saints face Buffalo Bills in Week 4 in first AFC East matchup in 2025

The New Orleans Saints' 2025 NFL schedule is here. See every matchup, key dates, and divisional games.

A collection of the best defensive photos from the Week 12 loss against the Buffalo Bills.

A collection of the best offensive photos from the Week 12 loss against the Buffalo Bills.

The New Orleans Saints take on the Buffalo Bills at the Caesars Superdome in Week 12 of the 2021 NFL season.

New Orleans Saints fans swarm the Caesars Superdome to cheer on the team against the Buffalo Bills on Thanksgiving night and welcome legend Drew Brees back to the Dome.

New Orleans Saints players and coaches prepare for Week 12 against the Buffalo Bills at home on November 25, 2021.

Buffalo Bills at New Orleans Saints game highlights from Thanksgiving night on Thursday Night Football in week 12 of the 2021 NFL season.

Saints fans get ready at Champions Square as the New Orleans Saints take on the Buffalo Bills in Week 12 on November 25, 2021 at the Caesars Superdome.

See the best moments from Saints fans in Buffalo for the Week 10 match up against the Buffalo Bills.

Check out the Saints locker room photos after their crushing win over the Bills.

Game action photos #1 from the Saints 47-10 win over the Bills in Week 10.

Plenty of fans in New York for the Saints-Bills matchup.

Check out the coaches and staff on hand for the Saints win vs. the Bills.

Pregame photos from the Saints vs Bills Week 10 matchup.

Watch highlights of the best plays from the Week 10 game between the New Orleans Saints and the Buffalo Bills during the 2017 NFL season.

Photos from the New Orleans Saints vs Buffalo Bills game on Sunday, October 27, 2013. Photos taken by Michael C. Hebert (New Orleans Saints photos)

New Orleans Saints quarterback Drew Brees puts on a show as he passes for over 300 yards and tosses a whopping five touchdowns in a dominant 35-17 victory over the Buffalo Bills in Week 8 of the 2013 NFL season.

Photos of New Orleans Saints fans at the Buffalo Bills game on Sunday, October. 27, 2013. Photos taken by Michael C. Hebert and Anne Talhelm. (New Orleans Saints photos)

Watch highlights from the Buffalo Bills vs. New Orleans Saints game in Week 3 of the 2009 NFL season.